Endometriosis

 

Endometriosis is a common condition in which the lining of the uterus or the endometrium spreads to other parts of the body.  Endometriosis can interfere with ovulation and conception and can also cause repeated miscarriage.  It is fairly common, affecting mostly women between the ages of 25 and 40. 

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Small pieces of womb lining are found outside the womb.

Endometriosis is most commonly found in the fallopian tubes, the ovaries, the bladder, the bowl, the intestines, the vagina and the rectum.  More Science...

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Endometriosis is graded 1 to 4. 

Reproductive specialists divide patients into one of four levels based upon what is seen at the time of their surgery:

 

  • Stage I: This is the lowest severity of endometriosis and is also referred to as minimal. It involves the presence of a few lesions or even microscopic presence noted on a biopsy specimen.
  • Stage II: Mild endometriosis is a more obvious disease with obvious implants of endometrium on anatomic structure but no distortion of the anatomy and minimal scarring.
  • Stage III: Referred to as moderate endometriosis, Stage III indicates a more extensive problem but without complete obstruction of fallopian tubes. Additionally, women with moderate endometriosis are more likely to have implants upon the ovary and sometimes even within it as well.
  • Stage IV: Severe endometriosis can be a devastating illness and is often associated with complete hysterectomy and removal of the ovaries to relieve symptoms. The extent of scarring obstructs one or both tubes.  More Science...

Since the diagnosis of endometriosis can only be made by identifying it at the time of surgery, the extent of the disease is based upon where it is located and the extent of the damage it has caused.  For some reason, there is a poor correlation between the severity of endometriosis and the resulting symptoms.  There is however a correlation with the "stage" of endometriosis and its impact upon fertility. [ x ]

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All endometriosis cells respond to the menstrual cycle.

Endometrial cells found in other parts of the body respond to the body's hormones in the same way as the cells in the womb lining. This means that every month the cells go through the menstrual cycle of thickening and bleeding.  However, because they have no way of leaving the body – the endometrial tissue is essentially ‘trapped’ which leads to pain, swelling and bleeding wherever the tissue is. More Science...

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Fertility can be affected in several ways.

Endometriosis impacts on fertility in a number of ways.

 

1) Endometriosis can impede the progress of the egg and sperm through the fallopian tubres.

 

2) Toxins can impair fertilisation of the egg.

 

3) Endometriosis can affect the immune system, causing the mother's overactive immune system to attack the embryo and sperm.

 

4) Endometriosis appears to reduce the chances of an egg successfully implanting in the uterus.  More Science...

As the Endometriosis implants grow and develop in the abdomen, the body tries to surround them with fibrous connective tissue (scar tissue). The body does this in an attempt to isolate the implants and prevent them from doing harm.

 

These fibrous growths also have the effect of making the implants stick to adjacent tissue, and in some cases organs can be ‘glued’ together. Also the blood from internal bleeding from the implants can form adhesions, so that an implant may be stuck to several different tissues. For example, an Endometriosis implant on the top of the uterus may cause the ovary and small intestine to become attached at the site of the implant.

 

If the adhesions caused by Endometriosis pinch off the fallopian tube or if they cause blockage to the opening of the fallopian tube, they could obstruct the merger of egg and sperm and prevent fertilization and conception. Also ectopic pregnancy is more common with Endometriosis, if the embryo can't travel to the womb. This type of obstruction can be easily diagnosed and surgically corrected.

 

Normally, the gentle contraction of the womb and fallopian tube aids the movement of egg and sperm to the outer third of the fallopian tube where fertilization occurs.  If there are high concentrations of endometriosis cells, however, the contractions may be too strong and expel the egg too quickly, preventing fertilization.

 

“Toxins” present in the peritoneal secretions of women suffering from endometriosis can also impair fertilisation of the egg, making a woman suffering from endometriosis about three times less likely to conceive per month of trying.


Endometriosis is also thought to be a possible cause of the woman's body attacking an embryo or the sperm.  Because sperm entering a woman’s body is “alien”, if a pregnancy is to be achieved, the woman’s immune system must avoid attacking the sperm or embryo.  However, endometriosis can cause the immune system to malfunction, causing an immune attack on the embryo and sperm.

 

Another factor which could cause infertility for women with Endometriosis, may be the over-production of prostaglandins. These are hormones which play an important role in the fertilization and implantation of the embryo. An excess of prostaglandins may interfere with these processes.

 

A study published in Fertility and Sterility "to investigate the effect of endometriosis on implantation", concluded that, in patients with endometriosis, implantation rate is low. Abnormal implantation, which may be secondary to endometrial dysfunction or embryotoxic environment, is a factor in endometriosis-associated subfertility.

The study analyzed 284 consecutive IVF cycles. Patients with endometriosis only were compared with an age-matched control group with tubal infertility and also to a group with unexplained infertility. Data from the endometriosis group was analyzed further in subgroups of minimal-mild (43 cycles) and moderate-severe (46 cycles).

Results showed that there was no difference in the number and the quality of oocytes retrieved and fertilization rates between the endometriosis, the tubal infertility, and the unexplained infertility groups. The quality and the number of embryos transferred in each group were comparable. A trend toward reduced pregnancy rate per transfer (14.8%) in the endometriosis versus tubal or unexplained infertility groups (25.7% and 23.3%, respectively) was observed. Implantation rate (gestational sac per transferred embryo) was significantly lower in the endometriosis versus the tubal infertility group (3.9% versus 8.1%; unexplained infertility group, 7.2%). Analysis of first cycles only across all groups revealed that the implantation rate also was significantly lower in the endometriosis versus the tubal infertility group (3.1% versus 9%; unexplained infertility group, 6.7%). Within the endometriosis group, although the pregnancy rate per cycle and per transfer were similar in subgroups, patients with minimal-mild endometriosis had the lowest implantation rate. [ x ]

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Diagnosis by Laparoscopy.

The most effective way to diagnose endometriosis is through an internal examination called a laparascopy.  The patient will be placed under general anaesthetic and a small viewing tube called a larascope will be passed into their body. This will enable the specialist to view the endometrial tissue and take a small sample (a biopsy) for testing.   More Science...

Interestingly, it has been found that between 30 to 40 percent of women undergoing laparoscopy as part of an infertility evaluation are found to have Endometriosis. [ x ]

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No known cure.

Whilst there is currently no cure for endometriosis, treatment options are designed to manage symptoms and include pain medication, hormone treatment or surgery. More Science...

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Surgery may reduce Symptoms.

Surgery can sometimes be used to remove the endometrial tissue, which in turn can help reduce the symptoms.  This type of surgery will depend on where the tissue is - and the endometrial tissue will return over time.

 

Many doctors feel that for a woman who has Endometriosis, the best chances of pregnancy occur during the six to nine months period following treatment with a laparoscopy procedure.  More Science...

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Endometriosis can lead to early miscarriage.

Endometriosis cells contain local hormones responsible for several processes, including ovulation, contraction of the uterus and immune interaction.  However, these local hormones seem to be out of phase with their release by the uterus, disrupting the normal menstrual cycle and possibly leading to early miscarriage.

 

Additionally, More than half of women with endometriosis (regardless of its severity) have a reduced chance of proper inplantation due to immunologic implantation dysfunction.  More Science...

One major group of hormones secreted by the normal endometrium is that of the prostaglandins. Prostaglandins are oil-based hormones found in nearly all the tissues of the body and are required for many bodily processes, including several stages of the menstrual cycle and pregnancy.

 

Prostaglandins are required for ovulation, regression of the corpus luteum (i.e., ending the monthly menstrual cycle), sperm motility, immune interaction, contraction of the uterus at birth and menstrual cramps. Endometriosis cells and the endometrium of the uterus are the richest source of prostaglandin production in the body.

 

However, the problem with Endometriosis cells includes:
- Prostaglandins are released into the abdomen instead of inside the womb
- Prostaglandins released by endometriosis cells seem to be out of phase with their release by the uterus. Prostaglandins are produced at the wrong time sending the wrong message.

For instance, there is a normal surge in prostaglandin F production at the end of the menstrual cycle, causing the effect of the copus luteum of the ovary to die down and signaling the start of a new menstrual cycle. The Endometriosis cells produce their own prostaglandin surge several days after that of the womb lining. This may be one of the main causes of very early miscarriage.

 

If a woman is a few days pregnant then the Endometriosis cells producing prostaglandin F would incorrectly signal the ovary to start a new menstrual cycle, causing the womb lining with the implanted egg to be expelled - and the consequence is an early miscarriage.

 

The most common form of immunologic implantation dysfunction involves the presence of antiphospholipid antibodies (APA) and about 40% of these APA+ women (i.e., 30% of all women with endometriosis) in addition have evidence of activated Natural Killer (NKa) cells in their uterine linings (endometria). It is this NKa activity that represents the most significant reason for immunologic implantation dysfunction in women with endometriosis. The exact reason for the NKa in women with endometriosis remains at best speculative. If present, NKa usually leads to destruction of the embryo's implanting "root system" (the trophoblast), leading to early rejection of the embryo even before there is clinical evidence of a pregnancy. In fact, in most such cases the woman will not even know that she in fact had a "mini-miscarriage".  Less often, the damaged embryo miscarries early in the first trimester. [ x ]

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IVF may be an effective means of conception.

In vitro fertilization (IVF) procedures are effective in improving fertility for some women with endometriosis.  IVF makes it possible to combine sperm and eggs in a laboratory and then place the resulting embryos into the woman’s uterus.  This helps to bypass toxins in the peritoneal fluid can impair fertilisation of the egg. More Science...

"Toxins" that impair fertilization of the egg are present in the peritoneal secretions of most women who have endometriosis, making impaired fertilization a feature of endometriosis regardless of its severity.  It is the main reason why women with endometriosis are about three times less likely to conceive per month of trying and why procedures such as intrauterine insemination do not substantially increase the chances of pregnancy over no treatment at all.  By bypassing the toxins with IVF, pregnancy rates improve dramatically, making it the treatment of choice for most endometriosis patients with infertility. [ x ]

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Evening Primrose Oil may help reduce symptoms. 

A natural anti-inflammatory, evening primrose oil can help reduce the pain of endometriosis, and is especially helpful with cramping.

 

There is some anecdotal evidence that long term use may actually aggravate endometriosis.  This has not been proven scientifically.  Current studies suggest Evening Primrose Oil is safe long-term.

 

Caution : Do not take Evening Primrose Oil after ovulation because if are pregnant, it can cause mild uterine contractions and prevent implantation.  More Science...

The types of fatty acids included in the diet influence the types of prostaglandins (local hormones) made. For example, series two prostaglandin (the type that trigger powerful contractions of the uterus) levels are increased when animal fat is included in the diet. In contrast, series one and series three prostaglandins (the type that don’t cause uterine contractions) are produced when the diet is higher in linoleic acid, which is found naturally in tuna and salmon oil. Evening primrose oil and starflower oil are also rich sources of linoleic acid, which is why they are often recommended for women suffering from period cramps and are especially helpful for women with endometriosis. [ x ]

Symptoms of Endometriosis

Whilst it is important to remember that many women with endometriosis will experience few or no symptoms at all, some women may experience any of the following :

 

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Pain and discomfort.

The most common symptom of endometriosis is pain and discomfort in the area where the tissue has located itself as it thickens and bleeds.   More Science...

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Painful or heavy periods.

The pain typically begins a few days before the period and usually lasts the whole of the period. It is different to normal period pain which is usually not as severe, and doesn't last as long.  More Science...

Primary dysmenorrhoea (painful periods) is caused by cramping in the uterine muscles — the uterus is a muscle and like all muscles it contracts and relaxes! Women don’t usually feel these muscles contract, unless it is a particularly strong contraction. With endometriosis, the pain associated with menstrual cramps is usually very intense and painful. During a contraction, blood supply to the uterus can be temporarily cut off. This deprives the muscle of oxygen, which causes pain.

 

The pain is caused by the series two prostaglandins. Series two prostaglandins help the uterus to shed the womb lining during menstruation by causing the contraction of the uterine muscles. Understandably, if too many of these prostaglandins are produced, then the contractions will be more severe and cause painful menstrual cramps — primary dysmenorrhoea.  [ x ]

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Pelvic pain.

Pelvic pain is one of the most common symptoms of Endometriosis.  Sometimes the pain is constant, but is usually worse on the days just before and during a period.  The pelvic pain can be excruciating and debilitating for many women. It may be experienced constantly, it may be intermittent or it may be related solely to the menstrual period. Pain can be provoked by certain activities such as walking, standing too long etc., or it may occur unpredictably.  More Science...

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Pain during sexual intercourse.

The pain is typically felt deep inside and may be felt during intercourse as well as up to 48 hours after sexual activity. It is often associated with endometriosis in the pouch of Douglas or adhesions in the pelvic cavity.   More Science...

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Bleeding or spotting between periods.

Endometriosis does not itself cause the uterus to bleed abnormally.  However, it does create problems, which can, in turn, lead to abnormal bleeding.  Some reasons for the bleeding can be :

* Ovarian endometriomas (chocolate cysts) can get large enough to put so much pressure on the rest of the ovary that it is not able to respond to stimulation, or is not able to complete the ovulation process. This then leads to abnormal hormone production and possible bleeding abnormalities.

* Ovaries can become encased by adhesions due to endometriosis. The endo irritates the tissues it's on, and the adhesion forms as the body attempts to wall off the offending area. When the ovary is entrapped this way, cysts can form and abnormal hormone production can result.  More Science...

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Diarrhoea or constipation.

Most bowel symptoms are not due to the presence of endometriosis on the surface of the bowel itself. Rather, they are usually due to irritation from implants (endometriosis cells) and nodules located in adjacent areas, such as the Pouch of Douglas, uterosacral ligaments, and rectovaginal septum.

 

In those cases where the endometrial implants are located on the bowel, the implants are usually lying on the outside surface of the bowel or rectum rather than in the bowel itself. Nevertheless, endometriosis can penetrate into and through the bowel wall on some occasions. The large bowel is a much more common site of endometriosis than the small bowel.

 

Some bowel symptoms are due to adhesions constricting, twisting, or pulling on the bowel. More Science...

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Adominal bloating.

Abdominal bloating may be a sign of endometriosis. It is thought to be due to inflammation in the pelvic cavity caused by the endometriosis.  Irritable Bowel Syndrome (IBS) can cause pelvic pain, and can also cause severe abdominal bloating. With IBS, the bloating is usually caused by intestinal gasses which expand and distend the abdomen and can cause severe pain and discomfort.  IBS is very common in women with Endometriosis. More Science...

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Fatigue.

Fatigue and Endometriosis seem to go hand in hand.  It is not known what causes the acute fatigue women suffer with Endometriosis, and is not often recognized as a symptom of Endometriosis.  However, fatigue can be one of the most debilitating aspects of the disease, and most women with endometriosis experience fatigue around the time of their period and some experience it throughout the month. The fatigue may be related to the constant pain and/or medication, or it could be the bodies reaction to the disease at a deeper level.  More Science...

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Low backache.

Lower back pain is another common but poorly recognized symptom that often accompanies period pain. It is commonly associated with endometriosis in the pouch of Douglas, uterosacral ligaments, and rectovaginal septum.  More Science...

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Difficulty or discomfort urinating.

This is an uncommon symptom of endometriosis.  The urinary tract symptoms of Endometriosis are usually the result of endometriosis lying on the outside of the bladder or irritation from endometrial implants lying on the front of the uterus.  More Science...

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Rectal bleeding.

This is an uncommon symptom of endometriosis.  The bowel symptoms of endometriosis are often overlooked or dismissed because many people think endometriosis affects only the reproductive organs. Many bowel symptoms are caused by irritation to the bowel from endometrial implants lying on adjacent areas such as the Pouch of Douglas and the back of the uterus, but some are due to endometrial deposits lying on the outside of the bowel wall.


The gastrointestinal disorder which is most common with Endometriosis is Irritable Bowel Syndrome which can cause many of the bowel symptoms mentioned above. Candida has also been found to be prevalent in women with Endometriosis, and this too can cause many distressing digestive upsets and discomfort.  More Science...

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Why have I got it?

Whilst the exact cause of endometriosis remains unknown, research continues and there are currently a number of theories including :

 

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Retrograde menstruation.

This is when some of the womb lining (the endometrium) flows backwards through the fallopian tubes into the abdomen, instead of leaving the body like usual menstrual blood. It is believed that retrograde menstruation happens to most women but that they are able to clear the tissue naturally without it becoming a problem. However, in some women the tissue embeds itself and grows, becoming endometriosis.   More Science...

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Genetic disposition.

Endometriosis is sometimes believed to be hereditary, if your mother suffered from endometriosis it is more likely that you will develop the condition. More Science...

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Immune dysfunction.

It is believed that some women are less able to effectively fight off endometriosis. Many women with the condition have been noted as having lower immunity to other conditions. More Science...

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Bloodstream transfer.

Researchers believe that endometriosis cells can get into the blood stream. This would explain how, in very rare cases, endometriosis cells are found in remote places such as the eyes or brain.  More Science...

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Metaplasia.

This is when one type of cell changes into another, the process that allows the human body to grow in the womb before birth. Some researchers believe that endometriosis could develop when the baby’s womb is first forming, or that the womb can retain the ability to transform cells.  More Science...

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